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Symptoms: In general, patients with a NSAID overdosage are asymptomatic. NSAID overdosage causes only minor CNS or gastrointestinal disturbances.
There have been isolated reports of more serious toxicity after ingestion of substantial quantities; they include seizures, coma and renal failure, and cardio-respiratory arrest may occur. Hepatic dysfunction, hypothrombinemia and metabolic acidosis are also reported.
Treatment: In case of overdosage appropriate supportive treatment is indicated and discontinuation of the medicine, antacids and proton-pump inhibitors may be indicated. There are no known specific antidotes. Dialysis does not significantly clear NSAIDs from the blood stream.
